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It also improves tendon, ligament, and bone healing, accurately implementing its own angiogenic effect in the healing

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Mandrika and colleagues (Biochem Pharmacol, 2001, PMID 11239505) examined melanocortin peptides on NF-B DNA binding in RAW 264.7 macrophage-like cells and reported evidence for dual mechanisms of action, and Kannengiesser and colleagues (Inflamm Bowel Dis, 2008, PMID 18092346) reported effects in murine colitis models that were partly independent of MC1R

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Techniques like colon massage, especially to the abdomen, can also help stimulate the gastrocolic reflex

It is generally considered safe for most people